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Translational medicine in hepatocellular carcinoma

Qiang Gao, Yinghong Shi, Xiaoying Wang, Jian Zhou, Shuangjian Qiu, Jia Fan

Frontiers of Medicine 2012, Volume 6, Issue 2, Pages 122-133 doi: 10.1007/s11684-012-0193-7

Abstract: In the past decade, tremendous progress has been achieved in the molecular stratification of HCCs forTo date, the molecular classification of HCCs has been carried out through transcriptomic, genetic andSuch research has led to identification of several potential molecular targets in HCC, and subsequentlyIn this article, we review the current knowledge of the molecular pathogenesis of HCC and outline potentialimmunotherapy and strategies targeting various components of the tumor microenvironment, as well as novel molecular

Keywords： hepatocellular carcinoma molecular classification molecular targeted therapies tumor microenvironment

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Precision medicine in acute lymphoblastic leukemia

Ching-Hon Pui

Frontiers of Medicine 2020, Volume 14, Issue 6, Pages 689-700 doi: 10.1007/s11684-020-0759-8

Abstract: Further improvement in outcome will need to rely more heavily on molecular therapeutic as well as immuno

Keywords： acute lymphoblastic leukemia molecular therapeutics targeted therapy tyrosine kinase inhibitors immunotherapy

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Molecular classification of non-small-cell lung cancer: diagnosis, individualized treatment, and prognosis

Yue Yu, Jie He

Frontiers of Medicine 2013, Volume 7, Issue 2, Pages 157-171 doi: 10.1007/s11684-013-0272-4

Abstract: Molecular biology techniques, particularly gene expression microarrays, proteomics, and next-generationsequencing, have recently been developed to facilitate effectively its molecular classification.The underlying etiology, pathogenesis, therapeutics, and prognosis of NSCLC based on an improved molecularThis review focuses on the molecular classification of NSCLC based on gene expression microarray technology

Keywords： non-small-cell lung cancer molecular typing individualized medicine molecular-targeted therapy gene expression

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Molecular authentication of the traditional Chinese medicine Tongren Dahuoluo Wan and its alternative

Jikun WANG, Jing DU, Meng CAO, Lu YAO, Suhua XIE, Jiafu CHEN, Xingbo ZHAO

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 3, Pages 353-357 doi: 10.15302/J-FASE-2017157

Abstract: Tongren Dahuoluo Wan has been a popular traditional Chinese medicine in international pharmaceuticalTo develop a simple and reliable molecular method for authenticating the two patent medicines, mitochondrialFor the patent medicine authentication, we set up a molecular diagnostic assay to resolve the difficultiesof low concentration of target DNAs and presence of PCR-inhibitory substances in this complex medicine, and discuss the experimental solutions for technical problems of molecular diagnostic assays.

Keywords： Tongren Dahuoluo Wan molecular diagnostic assay Eospalax baileyi Panthera pardus species-specific

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Molecular classification and precision therapy of cancer: immune checkpoint inhibitors

Yingyan Yu

Frontiers of Medicine 2018, Volume 12, Issue 2, Pages 229-235 doi: 10.1007/s11684-017-0581-0

Abstract: Taking gastric cancer as an example, its molecular classification is built on genome abnormalities, butas “genetic interpreters” or “genetic translators” and build a link between molecularSubsequently, by using their findings, oncologists will carry out targeted therapy based on molecular

Keywords： molecular classification precision medicine pembrolizumab PD-1/PD-L1 MSI-H

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Precision Burn Trauma Medicine: Application for Molecular Engineering Science

Kristen Jakubowski, Michael Poellmann, Raphael C. Lee

Engineering 2015, Volume 1, Issue 3, Pages 280-281 doi: 10.15302/J-ENG-2015073

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Molecular targeted therapy of gynecological malignant tumors: the development and challenge, from laboratory

Pengming SUN PhD, MD , Jalid SEHOULI PhD, MD , Lihui WEI BM ,

Frontiers of Medicine 2009, Volume 3, Issue 3, Pages 256-264 doi: 10.1007/s11684-009-0052-3

Abstract: More and more molecular drugs based on targeted therapy have been utilized in the treatment of gynecologicOther planned or ongoing trials currentlytargeted at molecular markers which may play important rolesin gynecological carcinogenesis andprogression suggest that combination chemotherapy with molecular

Keywords： target therapy gynecologic malignant tumors clinical trail molecular medicine

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Individualized medicine, health medicine, and constitutional theory in Chinese medicine

Qi Wang

Frontiers of Medicine 2012, Volume 6, Issue 1, Pages 1-7 doi: 10.1007/s11684-012-0173-y

Abstract: Individualized treatment in modern medicine is mainly established based on individual genome informationChinese constitutional theory developed in the 1970s expresses the principle behind Chinese health medicineIt promotes the study of the relationship of each constitution to diseases and Chinese medicine preparationdisease-differentiation, and syndrome-differentiation can be established for the development of individualized Chinese medicinetreatment and health medicine for the international medical community.

Keywords： individualized medicine health medicine constitutional theory in Chinese medicine

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Thinking and practice of accelerating transformation of traditional Chinese medicine from experiencemedicine to evidence-based medicine

Baoyan Liu, Yanhong Zhang, Jingqing Hu, Liyun He, Xuezhong Zhou

Frontiers of Medicine 2011, Volume 5, Issue 2, Pages 163-170 doi: 10.1007/s11684-011-0143-9

Abstract: in clinical practice, but without the benefit of undergoing the experimental medicine stage.medicine to Chinese medicine is appearing.The rapid transition and transformation from experience medicine to evidence-based medicine have becomeimportant content in the development of Chinese medicine., as well as transform and develop Chinese medicine from experience medicine to evidence-based medicine

Keywords： Chinese medicine experience medicine evidence-based medicine real world

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Clinical research of traditional Chinese medicine in big data era

Junhua Zhang,Boli Zhang

Frontiers of Medicine 2014, Volume 8, Issue 3, Pages 321-327 doi: 10.1007/s11684-014-0370-y

Abstract: preventive healthcare and symptom pattern differentiation for treatment in terms of traditional Chinese medicine

Keywords： big data traditional Chinese medicine clinical evaluation evidence based medicine

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Research on Origin of Traditional Chinese Medicine

Fu Youfeng

Strategic Study of CAE 2006, Volume 8, Issue 9, Pages 1-12

Abstract: , the author has explored the relationship between epidemic disease (especially bubonic plague) and medicineFrom the point of view that medicine comes of epidemic disease, the author has conducted research onrich resources of Chinese cultural relics, ancient writing and medical literature on medicine historyincluding the difference between ancient name and modem name of disease, difference between TCM and Western medicinepromotion of TCM achievement on epidemic disease and for the research on combination of TCM and Western medicine

Keywords： world medicine history history of TCM medicine origin plague cholera smallpox comparative medicine

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Practices, challenges, and opportunities: HIV/AIDS treatment with traditional Chinese medicine in China

Jian Wang, Wen Zou

Frontiers of Medicine 2011, Volume 5, Issue 2, Pages 123-126 doi: 10.1007/s11684-011-0124-z

Abstract: Traditional Chinese medicine (TCM) has become widely used in the treatment of acquired immune deficiency

Keywords： HIV/AIDS traditional Chinese medicine

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Traditional Chinese medicine in the new century

Jianxiang Liu, Zhu Chen

Frontiers of Medicine 2011, Volume 5, Issue 2, Pages 111-114 doi: 10.1007/s11684-011-0125-y

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Special issue on “Molecular Sensors and Molecular Logic Gates”

Luling Wu , Tony D. James

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 1, Pages 1-3 doi: 10.1007/s11705-021-2134-y

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Design of bio-oil additives via molecular signature descriptors using a multi-stage computer-aided molecular

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 2, Pages 168-182 doi: 10.1007/s11705-021-2056-8

Abstract: In this work, computer-aided molecular design tools were developed to design optimal solvents to upgradeAs different property prediction models consist different levels of structural information, molecularDue to the combinatorial nature of higher-order signatures, the complexity of a computer-aided molecular

Keywords： computer-aided molecular design bio-oil additives molecular signature descriptor